Carcinoembryonic antigen expression, antibody localisation and immunophotodetection of human colon cancer liver metastases in nude mice: A model for radioimmunotherapy

1996 ◽  
Vol 67 (2) ◽  
pp. 294-302 ◽  
Author(s):  
Charles-André Vogel ◽  
Marie C. Galmiche ◽  
Patrick Westermann ◽  
Lin-Quan Sun ◽  
André Pèlegrin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastases ◽  
Carcinoembryonic Antigen ◽  
Nude Mice ◽  
Antigen Expression ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Colon Cancer Liver Metastases

scholarly journals Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases

2011 ◽  
Vol 300 (2) ◽  
pp. 180-188 ◽  
Author(s):  
Michelle L. Varney ◽  
Seema Singh ◽  
Aihua Li ◽  
Rosemary Mayer-Ezell ◽  
Richard Bond ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastases ◽  
Small Molecule ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Colon Cancer Liver Metastases

Staurosporine Increases Carcinoembryonic Antigen Expression in a Human Colon Cancer Cell Line

2000 ◽  
Vol 12 (2) ◽  
pp. 167-172 ◽  
Author(s):  
A. Aquino ◽  
S.P. Prete ◽  
S. Baier ◽  
D. Cappelletti ◽  
J.W. Greiner ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Carcinoembryonic Antigen ◽  
Cell Line ◽  
Cancer Cell Line ◽  
Antigen Expression ◽  
Human Colon ◽  
Colon Cancer Cell Line ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer

A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice

Surgery Today ◽  
1993 ◽  
Vol 23 (5) ◽  
pp. 420-423 ◽  
Author(s):  
Toshiharu Furukawa ◽  
Tetsuro Kubota ◽  
Masahiko Watanabe ◽  
Tsong-Hong Kuo ◽  
Hideki Nishibori ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nude Mice ◽  
Human Colon ◽  
Cancer Tissue ◽  
Human Colon Cancer

Colonic mucosal changes in nude mice associated with orthotopic xenografts of human colon cancer cells

1990 ◽  
Vol 416 (5) ◽  
pp. 393-396 ◽  
Author(s):  
Koji Sekikawa ◽  
Jan W. Arends ◽  
Kees Verstijnen ◽  
Joop Kate ◽  
Bert Schutte ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Mucosal Changes ◽  
Orthotopic Xenografts ◽  
Human Colon Cancer Cells

scholarly journals Evaluation of Anti-Tumorigenic Effects of Diosmetin against Human Colon Cancer Xenografts in Athymic Nude Mice

Molecules ◽  
2019 ◽  
Vol 24 (14) ◽  
pp. 2522 ◽  
Author(s):  
Sanaz Koosha ◽  
Zahurin Mohamed ◽  
Ajantha Sinniah ◽  
Mohammed A. Alshawsh
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Human Colon ◽  
Tumor Growth Rate ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Apoptotic Protein ◽  
Hct 116

Colon cancer is the third most common type of cancer in the world. Diosmetin (Dis), a natural O-methylated flavone, has been reported to have anti-cancer effects against different types of cancer. Although the mechanisms of action of Dis against several cancer cell lines are well reported, in vivo anti-tumorigenesis properties of this compound are still obscure. Therefore, this study aimed to investigate the anti-tumorigenesis properties of Dis against HCT-116 colon cancer xenografts in nude mice. HCT-116 colon cancer cells were injected in NCr nu/nu nude mice and treatment with Dis was initiated after the tumor volumes reached 100 mm3 and continued for four weeks. On the sacrificing date nude mice treated with 100 mg/kg of Dis showed significant lower tumor volume (264 ± 238.3 mm3) as compared to the untreated group (1428.8 ± 459.6 mm3). Anti-apoptotic Bcl-2 protein was significantly downregulated, while apoptotic protein (Bax) was significantly overexpressed in nude mice treated with 100 mg/kg Dis as compared to untreated mice. In conclusion, our in vivo results indicate that Dis significantly reduces tumor growth rate of HCT-116 colon cancer cells in nude mice at a dose of 100 mg/kg, and has no toxic effects in ICR mice up to 2000 mg/kg.

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